Back to search

Article

A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice

2023-07-03

Abstract excerpt

Changes in genomic structures underlie phenotypic diversification in organisms. Amino acid-changing mutations affect pleiotropic functions of proteins, although little is known about how mutated proteins are adapted in existing developmental programs. Here we investigate the biological effects of a variant of the GLI3 transcription factor (GLI3 R1537C ) carried in Neanderthals and Denisovans, which are extinct ho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
21d49078-966f-5107-bb82-3ec8603da512
DOI
10.1101/2023.07.03.547394
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in miceDOI 10.1101/2023.07.03.547394
The molecular characterization of seven novel GLI family zinc finger 3 (GLI3) variants in Chinese families with limb malformationsSemantic proximity
Modern human changes in regulatory regions implicated in cortical developmentSemantic proximity
What you can learn from one gene: GLI3.Semantic proximity
Modern human changes in regulatory regions implicated in cortical development.Semantic proximity
Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactylySemantic proximity
Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly.Semantic proximity
GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseasesSemantic proximity
A Primate-Specific Isoform of PLEKHG6 Regulates Neurogenesis and Neuronal MigrationSemantic proximity
50 Years Ago in TheJournalofPediatrics: Spectrum of GLI3 Mutations.Semantic proximity
The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers.Semantic proximity
Modular Splicing is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3Semantic proximity
Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequenceSemantic proximity
Select a neighboring publication to make it the new centre.