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Article

Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum

26 Feb 2024

Abstract excerpt

Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq and spatial transcriptomic analyses of fetal samples from gestational week (GW) 13 to 18 to explore the emergence of cellular diversity and developmental programs in the developing human cerebellum. We identified transitory granule cell progenitors that are conserved...

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PMID: 38409116
DOI: 10.1038/s41421-024-00656-1

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