Article

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to the human brain evolution

2023-12-12

Abstract excerpt

Astrocytes contribute to the development and regulation of the higher-level functions of the brain, the critical targets of evolution. However, the molecular signature of foetal astrocyte evolution in primates is unknown. Here, to address this question, we use human, chimpanzee, and macaque induced pluripotent stem cell-derived foetal astrocytes (iAstrocytes). Human iAstrocytes are bigger and more complex than the...

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Literature Corpus work: 0ed79ad9-ceb1-5cc5-96aa-11c972effded
DOI: 10.1101/2023.12.12.570426

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