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The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

28 Nov 2018

Abstract excerpt

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-study integrating TWAS, GWAS, and eQTL analyses. We find the majority of P. falciparum parasites are...

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PMID: 30514877
DOI: 10.1038/s41467-018-07588-x

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