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Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?

Trends in parasitology - 1 Nov 2024

Kucharski Michal, Nayak Sourav, Gendrot Mathieu, Dondorp Arjen M, Bozdech Zbynek

Abstract excerpt

The genetics of Plasmodium as an intracellular, mostly haploid, sexually reproducing, eukaryotic organism with a complex life cycle, presents unprecedented challenges in studying drug resistance. This article summarizes current knowledge on the genetic basis of artemisinin resistance (AR) - a main component of current drug therapies for falciparum malaria. Although centered on nonsynonymous single-nucleotide...

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PMID: 39358163
DOI: 10.1016/j.pt.2024.09.002

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