Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background.

doi:10.1038/s41467-024-54915-6

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Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background.

Nature communications - 5 Dec 2024

Nayak Sourav, Peto Thomas J, Kucharski Michal, Tripura Rupam, Callery James J, Quang Huy Duong Tien, Gendrot Mathieu, Lek Dysoley, Nghia Ho Dang Trung, van der Pluijm Rob W, Dong Nguyen, Long Le Thanh, Vongpromek Ranitha, Rekol Huy, Hoang Chau Nguyen, Miotto Olivo, Mukaka Mavuto, Dhorda Mehul, von Seidlein Lorenz, Imwong Mallika, Roca Xavier, Day Nicholas P J, White Nicholas J, Dondorp Arjen M, Bozdech Zbynek

Abstract excerpt

The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other genetic variations. Here, we present population genomic/transcriptomic analyses of P. falciparum collected from patients...

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PMID: 39639029
DOI: 10.1038/s41467-024-54915-6
PMCID: PMC11621345

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