Genotype-First Approach Identifies an Association between rs28374544/FOG2S657G and Liver Disease through Alterations in mTORC1 Signaling.

doi:10.3390/genes15081098

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Genotype-First Approach Identifies an Association between rs28374544/FOG2S657G and Liver Disease through Alterations in mTORC1 Signaling.

Genes - 21 Aug 2024

Conlon Donna M, Kanakala Siri, Cherlin Tess, Ko Yi-An, Vitali Cecilia, Gurunathan Sharavana, Venkatesh Rasika, Woerner Jakob, Guare Lindsay A, Biobank Penn Medicine, Verma Anurag, Verma Shefali S, Guerraty Marie A

Abstract excerpt

Metabolic dysfunction-associated Fatty Liver Disease (MAFLD) has emerged as one of the leading cardiometabolic diseases. Friend of GATA2 (FOG2) is a transcriptional co-regulator that has been shown to regulate hepatic lipid metabolism and accumulation. Using meta-analysis from several different biobank datasets, we identified a coding variant of FOG2 (rs28374544, A1969G, S657G) predominantly found in individuals...

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PMID: 39202457
DOI: 10.3390/genes15081098
PMCID: PMC11353451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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