Article
A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.
Annual review of pharmacology and toxicology - 1 Jan 2015
Gross Eric R, Zambelli Vanessa O, Small Bryce A, Ferreira Julio C B, Chen Che-Hong, Mochly-Rosen Daria
Abstract excerpt
Asian Americans are one of the fastest-growing populations in the United States. A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic activity by approximately 60% to 80% in heterozygotes. Furthermore, this variant is associated with a...
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