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Article

Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.

Immunity - 21 Mar 2013

Ferguson Andrew L, Mann Jaclyn K, Omarjee Saleha, Ndung'u Thumbi, Walker Bruce D, Chakraborty Arup K

Abstract excerpt

A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral sequence variability among strains. Systematic means to guide immunogen design for highly variable pathogens like HIV are not available. Using computational models, we have developed an approach to translate available viral sequence...

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Identifiers

PMID: 23521886
DOI: 10.1016/j.immuni.2012.11.022
PMCID: PMC3728823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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