Article
Estimating HIV-1 fitness characteristics from cross-sectional genotype data.
PLoS computational biology - 1 Nov 2014
Gopalakrishnan Sathej, Montazeri Hesam, Menz Stephan, Beerenwinkel Niko, Huisinga Wilhelm
Abstract excerpt
Despite the success of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance development remains a major challenge. Resistant mutants display reduced drug susceptibilities, but in the absence of drug, they generally have a lower fitness than the wild type, owing to a mutation-incurred cost. The interaction...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.