Article

HCV E1 influences the fitness landscape of E2 and may enhance escape from E2-specific antibodies

2023-04-07

Abstract excerpt

The Hepatitis C virus (HCV) envelope glycoprotein E1 forms a noncovalent heterodimer with E2, the main target of neutralizing antibodies. How E1-E2 interactions influence viral fitness and contribute to resistance to E2-specific antibodies remains largely unknown. We investigate this problem using a combination of fitness landscape and evolutionary modelling. Our analysis indicates that E1 and E2 proteins collecti...

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Identifiers and source

Literature Corpus work: 797f9235-81d9-5078-a14c-5c75dc05b3f1
DOI: 10.1101/2023.04.03.535505

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