Article

Evolutionary modelling of HCV subtypes provides rationale for their different disease outcomes

2021-02-03

Abstract excerpt

Hepatitis C virus (HCV) is a leading cause of liver-associated disease and liver cancer. Of the major HCV subtypes, patients infected with subtype 1b have been associated with having a higher risk of developing chronic infection, cirrhosis and hepatocellular carcinoma. However, underlying reasons for this increased disease severity remain unknown. Here, we provide an evolutionary rationale, based on a comparative...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e3d8842-e27e-5c12-b5a9-73bcbe4f3ebc
DOI: 10.1101/2021.02.02.429470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary modelling of HCV subtypes provides rationale for their different disease outcomesDOI 10.1101/2021.02.02.429470Read

HCV E1 influences the fitness landscape of E2 and may enhance escape from E2-specific antibodiesSemantic proximity Read

Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes.Semantic proximity Read

Comparative Analysis of Within-Host Mutation Patterns and Diversity of Hepatitis C Virus Subtypes 1a, 1b, and 3a.Semantic proximity Read

High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progression.Semantic proximity Read

A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal AntibodiesSemantic proximity Read

Phylogeny and molecular evolution of the hepatitis C virus.Semantic proximity Read

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.Semantic proximity Read

Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.Semantic proximity Read

Evidence for separation of HCV subtype 1a into two distinct clades.Semantic proximity Read

Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay?Semantic proximity Read

A new evolutionary model for hepatitis C virus chronic infection.Semantic proximity Read

Acceleration of Hepatitis C Virus Envelope Evolution in Humans Is Consistent with Progressive Humoral Immune Selection during the Transition from Acute to Chronic InfectionSemantic proximity Read