Article
Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.
Human molecular genetics - 15 Feb 2019
Wang Heming, Cade Brian E, Sofer Tamar, Sands Scott A, Chen Han, Browning Sharon R, Stilp Adrienne M, Louie Tin L, Thornton Timothy A, Johnson W Craig, Below Jennifer E, Conomos Matthew P, Evans Daniel S, Gharib Sina A, Guo Xiuqing, Wood Alexis C, Mei Hao, Yaffe Kristine, Loredo Jose S, Ramos Alberto R, Barrett-Connor Elizabeth, Ancoli-Israel Sonia, Zee Phyllis C, Arens Raanan, Shah Neomi A, Taylor Kent D, Tranah Gregory J, Stone Katie L, Hanis Craig L, Wilson James G, Gottlieb Daniel J, Patel Sanjay R, Rice Ken, Post Wendy S, Rotter Jerome I, Sunyaev Shamil R, Cai Jianwen, Lin Xihong, Purcell Shaun M, Laurie Cathy C, Saxena Richa, Redline Susan, Zhu Xiaofeng
Abstract excerpt
Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Its prevalence and severity vary across ancestral background. Although OSA traits are heritable, few genetic associations have been identified. To identify genetic regions as...
Topics
- Aged
- Chromosome Mapping
- Female
- Ferrochelatase
- Genome-Wide Association Study
- Genotype
- Hispanic or Latino