Article
An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.
The Journal of allergy and clinical immunology - 1 Mar 2019
Gignoux Christopher R, Torgerson Dara G, Pino-Yanes Maria, Uricchio Lawrence H, Galanter Joshua, Roth Lindsey A, Eng Celeste, Hu Donglei, Nguyen Elizabeth A, Huntsman Scott, Mathias Rasika A, Kumar Rajesh, Rodriguez-Santana Jose, Thakur Neeta, Oh Sam S, McGarry Meghan, Moreno-Estrada Andres, Sandoval Karla, Winkler Cheryl A, Seibold Max A, Padhukasahasram Badri, Conti David V, Farber Harold J, Avila Pedro, Brigino-Buenaventura Emerita, Lenoir Michael, Meade Kelley, Serebrisky Denise, Borrell Luisa N, Rodriguez-Cintron William, Thyne Shannon, Joubert Bonnie R, Romieu Isabelle, Levin Albert M, Sienra-Monge Juan-Jose, Del Rio-Navarro Blanca Estela, Gan Weiniu, Raby Benjamin A, Weiss Scott T, Bleecker Eugene, Meyers Deborah A, Martinez Fernando J, Gauderman W James, Gilliland Frank, London Stephanie J, Bustamante Carlos D, Nicolae Dan L, Ober Carole, Sen Saunak, Barnes Kathleen, Williams L Keoki, Hernandez Ryan D, Burchard Esteban G
Abstract excerpt
BACKGROUND: Asthma is a common but complex disease with racial/ethnic differences in prevalence, morbidity, and response to therapies. OBJECTIVE: We sought to perform an analysis of genetic ancestry to identify new loci that contribute to asthma susceptibility. METHODS: We leveraged the mixed ancestry of 3902 Latinos and performed an admixture mapping meta-analysis for asthma susceptibility. We replicated...
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