Article
Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study.
Genetic epidemiology - 1 Nov 2014
Parker Margaret M, Foreman Marilyn G, Abel Haley J, Mathias Rasika A, Hetmanski Jacqueline B, Crapo James D, Silverman Edwin K, Beaty Terri H
Abstract excerpt
African Americans are admixed with genetic contributions from European and African ancestral populations. Admixture mapping leverages this information to map genes influencing differential disease risk across populations. We performed admixture and association mapping in 3,300 African American current or former smokers from the COPDGene Study. We analyzed estimated local ancestry and SNP genotype information to...
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