Article
Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.
Scientific reports - 27 Jan 2022
Wang Heming, Kurniansyah Nuzulul, Cade Brian E, Goodman Matthew O, Chen Han, Gottlieb Daniel J, Gharib Sina A, Purcell Shaun M, Lin Xihong, Saxena Richa, Zhu Xiaofeng, Durda Peter, Tracy Russel, Liu Yongmei, Taylor Kent D, Johnson W Craig, Gabriel Stacey, Smith Joshua D, Aguet François, Ardlie Kirstin, Blackwell Tom, Reiner Alexander P, Rotter Jerome I, Rich Stephen S, Redline Susan, Sofer Tamar
Abstract excerpt
Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent admixture mapping and gene enrichment analyses. However, its causal contribution was unclear. In this study, we performed pathway-level transcriptional Mendelian...
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