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Article

Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.

Human molecular genetics - 1 Dec 2016

Wang Heming, Cade Brian E, Chen Han, Gleason Kevin J, Saxena Richa, Feng Tao, Larkin Emma K, Vasan Ramachandran S, Lin Honghuang, Patel Sanjay R, Tracy Russell P, Liu Yongmei, Gottlieb Daniel J, Below Jennifer E, Hanis Craig L, Petty Lauren E, Sunyaev Shamil R, Frazier-Wood Alexis C, Rotter Jerome I, Post Wendy, Lin Xihong, Redline Susan, Zhu Xiaofeng

Abstract excerpt

Genetic determinants of sleep-disordered breathing (SDB), a common set of disorders that contribute to significant cardiovascular and neuropsychiatric morbidity, are not clear. Overnight nocturnal oxygen saturation (SaO2) is a clinically relevant and easily measured indicator of SDB severity but its genetic contribution has never been studied. Our recent study suggests nocturnal SaO2 is heritable. We performed...

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Identifiers

PMID: 27798093
DOI: 10.1093/hmg/ddw324
PMCID: PMC6078634

Genes

ANGPT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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