Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

doi:10.1186/s13073-021-00917-8

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Article

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Genome medicine - 26 Aug 2021

Cade Brian E, Lee Jiwon, Sofer Tamar, Wang Heming, Zhang Man, Chen Han, Gharib Sina A, Gottlieb Daniel J, Guo Xiuqing, Lane Jacqueline M, Liang Jingjing, Lin Xihong, Mei Hao, Patel Sanjay R, Purcell Shaun M, Saxena Richa, Shah Neomi A, Evans Daniel S, Hanis Craig L, Hillman David R, Mukherjee Sutapa, Palmer Lyle J, Stone Katie L, Tranah Gregory J, Abecasis Gonçalo R, Boerwinkle Eric A, Correa Adolfo, Cupples L Adrienne, Kaplan Robert C, Nickerson Deborah A, North Kari E, Psaty Bruce M, Rotter Jerome I, Rich Stephen S, Tracy Russell P, Vasan Ramachandran S, Wilson James G, Zhu Xiaofeng, Redline Susan

Abstract excerpt

BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. METHODS: The study sample was comprised of 7988 individuals of diverse...

Topics

Alleles
Chromatin Immunoprecipitation Sequencing
Female
Gene Expression Regulation
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Genotype

Humans

Male

National Heart, Lung, and Blood Institute (U.S.)

Phenotype

Precision Medicine

Research

Signal Transduction

Sleep Apnea Syndromes

United States

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 34446064
DOI: 10.1186/s13073-021-00917-8
PMCID: PMC8394596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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