Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based mendelian randomization study

Abstract excerpt

Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent admixture mapping and gene enrichment analyses. However, its causal contribution was unclear. In this study, we performed pathway-level transcriptional Mendelian rand...

Topics

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• Datasets as Topic
• Heme
• Iron
• Mendelian Randomization Analysis
• Metabolic Networks and Pathways
• Polysomnography
• Sleep Apnea, Obstructive
• Up-Regulation

Identifiers and source

Literature Corpus work

9e2fe3e7-e091-50ba-83ac-9cda3404a748

DOI

10.21203/rs.3.rs-966970/v1