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Article

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

7 Jul 2009

Abstract excerpt

Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non-small cell lung cancer (NSCLC), high HIF2alpha levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene VEGF or VEGFR2 improves clinical outcomes. However, whether HIF2alpha is causal in imparting this poor prognosis...

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PMID: 19662677
DOI: 10.1172/jci38443

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