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Article

Genomic landscape and prognosis of patients with TP53-mutated non-small cell lung cancer

1 Feb 2022

Abstract excerpt

Background: The TP53 tumor suppressor gene plays an important role in preventing and inhibiting the growth of tumor by regulating cell cycle, apoptosis and DNA repair. Meanwhile, the TP53 gene is one of the most frequently altered gene in non-small cell lung cancer (NSCLC) patients. Mutant TP53 (TP53-MUT) may lose tumor suppressor activity and gain tumor promoting functions, which play an important role in cancer...

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PMID: 35280362
DOI: 10.21037/atm-22-412

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