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Article

MST4 plays dual roles in lung adenocarcinoma by regulating homeostasis of wild-type and mutant p53 protein.

Oncogene - 1 Jul 2026

Zhang Minghui, Hu Changwei, Liu Huilong, Zhang Chenxi, Shu Qipeng, Kang Yu-Jian, Ding Yuetian, Zhang Jin, Hu Zhenghui, Wang Haokai, Zhang Youfan, Zhang Ze-Yan, Li Shangze

Abstract excerpt

Mutations are highly prevalent in the TP53 tumor suppressor gene, which encodes p53, in lung adenocarcinoma (LUAD). However, targeted therapies centered on p53 mutations remain challenging. Here, we found MST4 highly expressed in LUAD and linked to patient survival. Functional assays using CRISPR-generated MST4-knockout LUAD cell lines revealed context-dependent dual roles of MST4: tumor-suppressive in wild-type...

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Share to Adenocarcinoma of Lung
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Intracellular Signaling Peptides and Proteins

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

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Source

Open in PubMed Open full text

Identifiers

PMID: 42204266
DOI: 10.1038/s41388-026-03824-7
PMCID: PMC13286987

Genes

MDM2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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