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Article

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.

Carcinogenesis - 1 Feb 2012

Yeudall W Andrew, Vaughan Catherine A, Miyazaki Hiroshi, Ramamoorthy Mahesh, Choi Mi-Yon, Chapman Christopher G, Wang Huixin, Black Elena, Bulysheva Anna A, Deb Swati Palit, Windle Brad, Deb Sumitra

Abstract excerpt

The role of dominant transforming p53 in carcinogenesis is poorly understood. Our previous data suggested that aberrant p53 proteins can enhance tumorigenesis and metastasis. Here, we examined potential mechanisms through which gain-of-function (GOF) p53 proteins can induce motility. Cells expressing GOF p53 -R175H, -R273H and -D281G showed enhanced migration, which was reversed by RNA interference (RNAi) or...

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Share to Acetylation
Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22114072
DOI: 10.1093/carcin/bgr270

Genes

CXCL5
CXCL8
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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