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Article

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.

Cancer discovery - 12 Dec 2023

Efe Gizem, Dunbar Karen J, Sugiura Kensuke, Cunningham Katherine, Carcamo Saul, Karaiskos Spyros, Tang Qiaosi, Cruz-Acuña Ricardo, Resnick-Silverman Lois, Peura Jessica, Lu Chao, Hasson Dan, Klein-Szanto Andres J, Taylor Alison M, Manfredi James J, Prives Carol, Rustgi Anil K

Abstract excerpt

TP53 mutations are frequent in esophageal squamous cell carcinoma (ESCC) and other SCCs and are associated with a proclivity for metastasis. Here, we report that colony-stimulating factor-1 (CSF-1) expression is upregulated significantly in a p53-R172H-dependent manner in metastatic lung lesions of ESCC. The p53-R172H-dependent CSF-1 signaling, through its cognate receptor CSF-1R, increases tumor cell invasion...

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Source

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Identifiers

PMID: 37676642
DOI: 10.1158/2159-8290.CD-23-0601
PMCID: PMC10841313

Genes

BRD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.PMID 37676642Read ↗

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