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Article

Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma

7 Aug 2019

Abstract excerpt

Despite the propensity for gastric and esophageal adenocarcinomas to select for recurrent missense mutations in TP53 , the precise functional consequence of these mutations remains unclear. Here we report that endogenous mRNA and protein levels of mutant p53 were elevated in cell lines and patients with gastric and esophageal cancer. Functional studies showed that mutant p53 was sufficient, but not necessary, for...

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Identifiers

PMID: 31391338
DOI: 10.1172/jci.insight.128439

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