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Article

The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer

7 May 2019

Abstract excerpt

Lung cancer is the leading cause of cancer-related deaths in the USA, and alterations in the tumor suppressor gene TP53 are the most frequent somatic mutation among all histologic subtypes of lung cancer. Mutations in TP53 frequently result in a protein that exhibits not only loss of tumor suppressor capability but also oncogenic gain-of-function (GOF). The canonical p53 hotspot mutants R175H and R273H, for...

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PMID: 31067569
DOI: 10.1093/carcin/bgz087

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