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Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus

31 Oct 2018

Abstract excerpt

The control of virulence regulator/sensor kinase (CovRS) two-component system is critical to the infectivity of group A streptococcus (GAS), and CovRS inactivating mutations are frequently observed in GAS strains causing severe human infections. CovS modulates the phosphorylation status and with it the regulatory effect of its cognate regulator CovR via its kinase and phosphatase activity. However, the...

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PMID: 30379939
DOI: 10.1371/journal.ppat.1007354

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