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CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A <i>Streptococcus</i> Virulence Factor-Encoding Genes

19 May 2009

Abstract excerpt

To colonize and cause disease at distinct anatomical sites, bacterial pathogens must tailor gene expression in a microenvironment-specific manner. The molecular mechanisms that control the ability of the human bacterial pathogen group A Streptococcus (GAS) to transition between infection sites have yet to be fully elucidated. A key regulator of GAS virulence gene expression is the CovR-CovS two-component...

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PMID: 19451242
DOI: 10.1128/iai.01560-08

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