Article

Ectopic expression of the sensor CovS cytosolic domain confers phosphatase activity and full virulence to the M1T1 CovSY39H attenuated variant of group A <i>Streptococcus</i>

2025-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Group A Streptococcus (GAS) causes a wide variety of diseases ranging from mild, noninvasive, such as pharyngitis and impetigo, to life-threatening infections, such as necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). The two-component CovR/S system, comprising the sensor kinase CovS and transcription factor CovR, is a central regulator of GAS virulence. An attenuated ph...

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Literature Corpus work: a5897945-e5ef-560d-8b8f-41aca0a7dc80
DOI: 10.1101/2025.07.30.667676

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