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Article

Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci.

mSystems - 31 Aug 2023

DebRoy Sruti, Shropshire William C, Vega Luis, Tran Chau, Horstmann Nicola, Mukherjee Piyali, Selvaraj-Anand Selvalakshmi, Tran Truc T, Bremer Jordan, Gohel Marc, Arias Cesar A, Flores Anthony R, Shelburne Samuel A

Abstract excerpt

Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. Additionally, based on studies in emm1 GAS, hyperencapsulation is thought to limit transmission of CovRS-mutated strains by...

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PMID: 37358280
DOI: 10.1128/msystems.00227-23
PMCID: PMC10470059

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