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Article

Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease.

Microbial pathogenesis - 1 May 2006

Dalton Tracy L, Hobb Rhonda I, Scott June R

Abstract excerpt

The global regulatory two-component system CovR/S controls expression of about 15% of the Streptococcus pyogenes (group A streptococcus; GAS) genome. Recently, we found that CovS plays a pivotal role in general stress response of this strictly human pathogen. Therefore, we expected that both CovS and CovR might affect virulence. In this work, mice were inoculated subcutaneously with isogenic nonpolar covR and...

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Identifiers

PMID: 16542816
DOI: 10.1016/j.micpath.2006.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease.PMID 16542816Read ↗

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