Article
Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence.
PloS one - 1 Jan 2014
Mayfield Jeffrey A, Liang Zhong, Agrahari Garima, Lee Shaun W, Donahue Deborah L, Ploplis Victoria A, Castellino Francis J
Abstract excerpt
The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isolated from patients with virulent invasive diseases...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.