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CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus

18 Feb 2022

Abstract excerpt

The control of virulence gene regulator (CovR), also called caspsule synthesis regulator (CsrR), is critical to how the major human pathogen group A Streptococcus fine-tunes virulence factor production. CovR phosphorylation (CovR~P) levels are determined by its cognate sensor kinase CovS, and functional abrogating mutations in CovS can occur in invasive GAS isolates leading to hypervirulence. Presently, the...

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PMID: 35180278
DOI: 10.1371/journal.ppat.1010341

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