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Article

Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae.

Nature communications - 24 Oct 2024

Claverie Cosme, Coppolino Francesco, Mazzuoli Maria-Vittoria, Guyonnet Cécile, Jacquemet Elise, Legendre Rachel, Sismeiro Odile, De Gaetano Giuseppe Valerio, Teti Giuseppe, Trieu-Cuot Patrick, Tazi Asmaa, Beninati Concetta, Firon Arnaud

Abstract excerpt

Bacterial two-component systems (TCSs) are signaling modules that control physiology, adaptation, and host interactions. A typical TCS consists of a histidine kinase (HK) that activates a response regulator via phosphorylation in response to environmental signals. Here, we systematically test the effect of inactivating the conserved phosphatase activity of HKs to activate TCS signaling pathways. Transcriptome...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39448655
DOI: 10.1038/s41467-024-53439-3
PMCID: PMC11502775

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