Article
Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae.
Nature communications - 24 Oct 2024
Claverie Cosme, Coppolino Francesco, Mazzuoli Maria-Vittoria, Guyonnet Cécile, Jacquemet Elise, Legendre Rachel, Sismeiro Odile, De Gaetano Giuseppe Valerio, Teti Giuseppe, Trieu-Cuot Patrick, Tazi Asmaa, Beninati Concetta, Firon Arnaud
Abstract excerpt
Bacterial two-component systems (TCSs) are signaling modules that control physiology, adaptation, and host interactions. A typical TCS consists of a histidine kinase (HK) that activates a response regulator via phosphorylation in response to environmental signals. Here, we systematically test the effect of inactivating the conserved phosphatase activity of HKs to activate TCS signaling pathways. Transcriptome...
Topics
- Streptococcus agalactiae
- Histidine Kinase
- Gene Expression Regulation, Bacterial
- Bacterial Proteins
- Signal Transduction
- Phosphorylation
- Gene Regulatory Networks
- Humans
- Mutation