Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus.

Infection and immunity - 1 Mar 2015

Horstmann Nicola, Sahasrabhojane Pranoti, Saldaña Miguel, Ajami Nadim J, Flores Anthony R, Sumby Paul, Liu Chang-Gong, Yao Hui, Su Xiaoping, Thompson Erika, Shelburne Samuel A

Abstract excerpt

Two-component gene regulatory systems (TCSs) are a major mechanism by which bacteria respond to environmental stimuli and thus are critical to infectivity. For example, the control of virulence regulator/sensor kinase (CovRS) TCS is central to the virulence of the major human pathogen group A Streptococcus (GAS). Here, we used a combination of quantitative in vivo phosphorylation assays, isoallelic strains that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histidine Kinase

Share to Intracellular Signaling Peptides and Proteins

Share to Repressor Proteins

Share to Serogroup

Share to Streptococcus pyogenes

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 25561708
DOI: 10.1128/IAI.02659-14
PMCID: PMC4333468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus.PMID 25561708Read ↗

Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcusSemantic proximity Read ↗

Dual-Site Phosphorylation of the Control of Virulence Regulator Impacts Group A Streptococcal Global Gene Expression and PathogenesisSemantic proximity Read ↗

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A StreptococcusSemantic proximity Read ↗

Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae.Semantic proximity Read ↗

Ectopic expression of the sensor CovS cytosolic domain confers phosphatase activity and full virulence to the M1T1 CovSY39H attenuated variant of group A <i>Streptococcus</i>Semantic proximity Read ↗

CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes.Semantic proximity Read ↗

Role of serine/threonine phosphatase (SP-STP) in Streptococcus pyogenes physiology and virulence.Semantic proximity Read ↗

CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A <i>Streptococcus</i> Virulence Factor-Encoding GenesSemantic proximity Read ↗

Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease.Semantic proximity Read ↗

The CovR regulatory network drives the evolution of Group B Streptococcus virulenceSemantic proximity Read ↗

The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA.Semantic proximity Read ↗

Signal-independent activation reveals two-component regulatory networksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.