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Article

Subclonal TP53 copy number is associated with prognosis in multiple myeloma

29 Oct 2018

Abstract excerpt

Abstract Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of TP53 copy number, we profiled tumors from 1777 newly diagnosed Myeloma XI trial patients with multiplex ligation-dependent probe amplification (MLPA). Subclonal TP53 deletions were independently associated with shorter overall...

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PMID: 30373884
DOI: 10.1182/blood-2018-06-857250

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