Article
Molecular spectrum of TP53 mutations in plasma cell dyscrasias by next generation sequencing: an Italian cohort study and overview of the literature.
Oncotarget - 19 Apr 2016
Lionetti Marta, Barbieri Marzia, Manzoni Martina, Fabris Sonia, Bandini Cecilia, Todoerti Katia, Nozza Filomena, Rossi Davide, Musto Pellegrino, Baldini Luca, Neri Antonino
Abstract excerpt
The prevalence of TP53 mutations greatly varies between tumor types; in multiple myeloma (MM) they were rarely detected at presentation, while increased frequency was reported with disease progression. Using next-generation sequencing, we analyzed TP53 exons 4-9 in a large representative cohort comprising patients with MM at diagnosis and more aggressive forms of plasma cell (PC) dyscrasia, identifying mutations...
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