Article
High-Throughput Copy Number Profiling by Digital Multiplex Ligation-Dependent Probe Amplification in Multiple Myeloma.
The Journal of molecular diagnostics : JMD - 1 Nov 2018
Kosztolányi Szabolcs, Kiss Richárd, Atanesyan Lilit, Gángó Ambrus, de Groot Karel, Steenkamer Maryvonne, Jáksó Pál, Matolcsy András, Kajtár Béla, Pajor László, Szuhai Károly, Savola Suvi, Bödör Csaba, Alpár Donát
Abstract excerpt
Multiple myeloma (MM) is a genetically heterogeneous disease with a diverse clinical outcome. Copy number alterations (CNAs), including whole chromosome and subchromosomal gains and losses, are common contributors of the pathogenesis and have demonstrated prognostic impact in MM. We tested the performance of digital multiplex ligation-dependent probe amplification (digitalMLPA), a novel technique combining MLPA...
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