Article
Prognostic significance of copy-number alterations in multiple myeloma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2009
Avet-Loiseau Hervé, Li Cheng, Magrangeas Florence, Gouraud Wilfried, Charbonnel Catherine, Harousseau Jean-Luc, Attal Michel, Marit Gerald, Mathiot Claire, Facon Thierry, Moreau Philippe, Anderson Kenneth C, Campion Loïc, Munshi Nikhil C, Minvielle Stéphane
Abstract excerpt
PURPOSE: Chromosomal aberrations are a hallmark of multiple myeloma but their global prognostic impact is largely unknown. PATIENTS AND METHODS: We performed a genome-wide analysis of malignant plasma cells from 192 newly diagnosed patients with myeloma using high-density, single-nucleotide polymorphism (SNP) arrays to identify genetic lesions associated with prognosis. RESULTS: Our analyses revealed deletions...
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