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Article

Clonal hematopoiesis impacts frailty in newly diagnosed multiple myeloma patients: a retrospective multicenter analysis.

Scientific reports - 26 Nov 2024

Gelli Elisa, Martinuzzi Claudia, Soncini Debora, Conticello Concetta, Ladisa Francesco, Giorgetti Giulia, Truffelli Dario, Traverso Isabella, Lai Francesco, Guolo Fabio, Miglino Maurizio, Cagnetta Antonia, Laudisi Antonella, Aquino Sara, Derudas Daniele, Di Raimondo Francesco, Coviello Domenico A, Lemoli Roberto M, Cea Michele

Abstract excerpt

Somatic mutations of hematopoietic cells in the peripheral blood of normal individuals refer to clonal hematopoiesis of indeterminate potential (CHIP), which is associated with a 0.5-1% risk of progression to hematological malignancies and cardiovascular diseases. CHIP has also been reported in Multiple Myeloma (MM) patients, but its biological relevance remains to be elucidated. In this study, high-depth...

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Identifiers

PMID: 39592674
DOI: 10.1038/s41598-024-79748-7
PMCID: PMC11599865

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