Article
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.
Cancer cell - 13 Jan 2014
Lohr Jens G, Stojanov Petar, Carter Scott L, Cruz-Gordillo Peter, Lawrence Michael S, Auclair Daniel, Sougnez Carrie, Knoechel Birgit, Gould Joshua, Saksena Gordon, Cibulskis Kristian, McKenna Aaron, Chapman Michael A, Straussman Ravid, Levy Joan, Perkins Louise M, Keats Jonathan J, Schumacher Steven E, Rosenberg Mara, Getz Gad, Golub Todd R
Abstract excerpt
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity. We observed frequent mutations in KRAS (particularly in previously treated patients), NRAS, BRAF, FAM46C, TP53, and DIS3...
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