Article

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications

2025-01-14

Abstract excerpt

Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy characterized by clonal evolution, genetic instability, and interactions with a supportive tumor microenvironment. These factors contribute to treatment resistance, disease progression, and significant variability in clinical outcomes among patients. This review explores the mechanisms underlying MM progression, including the genetic and e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a644f301-8282-5b25-9ebd-3ecad15ba27e
DOI: 10.20944/preprints202501.1092.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical ImplicationsDOI 10.20944/preprints202501.1092.v1Read

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical ImplicationsSemantic proximity Read

Single-cell sequencing reveals the mechanisms of multiple myeloma progression: clarity or confusion?Semantic proximity Read

Single-Cell Profiling in Multiple Myeloma: Insights, Problems, and PromisesSemantic proximity Read

A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.Semantic proximity Read

Genomic heterogeneity in multiple myeloma.Semantic proximity Read

Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple MyelomaSemantic proximity Read

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomicsSemantic proximity Read

Genome Instability in Multiple Myeloma: Facts and FactorsSemantic proximity Read

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.Semantic proximity Read

Genomic complexity of multiple myeloma and its clinical implications.Semantic proximity Read

The Evolving Role of Genomic Technologies in Multiple Myeloma: Implications for Diagnosis, Risk Stratification and Resistance.Semantic proximity Read

Clonal Evolution in Multiple Myeloma.Semantic proximity Read