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Article

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection

29 Oct 2018

Abstract excerpt

Tissue-resident memory CD8 T (TRM) cells defend against microbial reinfections at mucosal barriers; determinants driving durable TRM cell responses in non-mucosal tissues, which often harbor opportunistic persistent pathogens, are unknown. JC polyomavirus (JCPyV) is a ubiquitous constituent of the human virome. With altered immunological status, JCPyV can cause the oft-fatal brain demyelinating disease...

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PMID: 30372487
DOI: 10.1371/journal.ppat.1007365

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