Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virus-specific CD4+ T cells contribute to clearance of human metapneumovirus despite exhibiting an impaired phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2025

Lamens Kristina D, Lan Jie, Eddens Taylor, Rogers Meredith C, Tometich Justin T, Hand Timothy W, Williams John V

Abstract excerpt

Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in pediatric, elderly, and immunocompromised populations. Clearance of HMPV relies primarily on the destruction of infected cells by cytotoxic CD8+ T cells. However, signals provided by CD4+ helper T cells significantly impact the magnitude and effectiveness of CD8+ T cells. The role of CD4+ helper T cells in the immune response to...

Topics

Metapneumovirus
Animals
Paramyxoviridae Infections
Mice
Humans
CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Programmed Cell Death 1 Receptor
Mice, Inbred C57BL
Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

CD40 Ligand

Phenotype

Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 40365919
DOI: 10.1093/jimmun/vkaf076
PMCID: PMC12313423

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virus-specific CD4+ T cells contribute to clearance of human metapneumovirus despite exhibiting an impaired phenotype.PMID 40365919Read ↗

Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype.Semantic proximity Read ↗

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infectionSemantic proximity Read ↗

Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.Semantic proximity Read ↗

The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection.Semantic proximity Read ↗

Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine designSemantic proximity Read ↗

Cutting Edge: Murine Cytomegalovirus Induces a Polyfunctional CD4 T Cell ResponseSemantic proximity Read ↗

Immune determinants of pegivirus persistence, control, and cross-species infection in the laboratory mouseSemantic proximity Read ↗

Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirusSemantic proximity Read ↗

CD4 + and CD8 + T cells are required to prevent SARS-CoV-2 persistence in the nasal compartmentSemantic proximity Read ↗

Single-epitope DNA vaccination prevents exhaustion and facilitates a broad antiviral CD8+ T cell response during chronic viral infection.Semantic proximity Read ↗

Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.Semantic proximity Read ↗

Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus InfectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.