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Article

Virus-specific CD4+ T cells contribute to clearance of human metapneumovirus despite exhibiting an impaired phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2025

Lamens Kristina D, Lan Jie, Eddens Taylor, Rogers Meredith C, Tometich Justin T, Hand Timothy W, Williams John V

Abstract excerpt

Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in pediatric, elderly, and immunocompromised populations. Clearance of HMPV relies primarily on the destruction of infected cells by cytotoxic CD8+ T cells. However, signals provided by CD4+ helper T cells significantly impact the magnitude and effectiveness of CD8+ T cells. The role of CD4+ helper T cells in the immune response to...

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Identifiers

PMID: 40365919
DOI: 10.1093/jimmun/vkaf076
PMCID: PMC12313423

Genes

CD4

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