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T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

7 Nov 2022

Abstract excerpt

JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease in immunocompromised patients. Inherited and acquired T cell deficiencies are associated with PML. The incidence of PML is increasing with the introduction of new immunomodulatory agents, several of which target T cells or B cells. PML patients often carry mutations in the JCPyV VP1 capsid protein,...

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PMID: 36341713
DOI: 10.7554/elife.83030

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