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CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis

29 Dec 2011

Abstract excerpt

CD4 T cell activation during peripheral infections not only is essential in inducing protective CD8 T cell memory but also promotes CD8 T cell function and survival. However, the contributions of CD4 T cell help to antiviral CD8 T cell immunity during central nervous system (CNS) infection are not well established. Encephalitis induced by the sublethal coronavirus JHMV was used to identify when CD4 T cells...

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PMID: 22205741
DOI: 10.1128/jvi.06797-11

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