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Isovitexin, a Potential Candidate Inhibitor of Sortase A of Staphylococcus aureus USA300

28 Sept 2018

Abstract excerpt

Staphylococcus aureus causes a broad variety of diseases.The spread of multidrug-resistant S. aureus highlights the need to develop new ways to combat S. aureus infections.Sortase A (SrtA) can anchor proteins containing LPXTG binding motifs to the bacteria surface and plays a key role in S. aureus infections, making it a promising antivirulence target.In the present study, we used a SrtA activity inhibition assay...

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PMID: 30369109
DOI: 10.4014/jmb.1802.02014

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