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Involvement of Sortase Anchoring of Cell Wall Proteins in Biofilm Formation by Streptococcus mutans

20 May 2005

Abstract excerpt

Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins were also found to be up-regulated in biofilms versus planktonic cells and mutations in these genes...

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PMID: 15908410
DOI: 10.1128/iai.73.6.3773-3777.2005

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