Article
Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development
8 Feb 2019
Abstract excerpt
ABSTRACT Sortases cleave short peptide motif sequences at the C-terminal end of secreted surface protein precursors and either attach these polypeptides to the peptidoglycan of Gram-positive bacteria or promote their assembly into pilus structures that are also attached to peptidoglycan. Sortase A, the enzyme first identified in the human pathogen Staphylococcus aureus , binds LPXTG motif sorting signals, cleaves...