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The divergent roles of sortase in the biology of Gram-positive bacteria

13 Jun 2021

Abstract excerpt

The bacterial cell wall contains numerous surface-exposed proteins, which are covalently anchored and assembled by a sortase family of transpeptidase enzymes. The sortase are cysteine transpeptidases that catalyzes the covalent attachment of surface protein to the cell wall peptidoglycan. Among the reported six classes of sortases, each distinct class of sortase plays a unique biological role in anchoring a...

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PMID: 34195501
DOI: 10.1016/j.tcsw.2021.100055

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